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G‐quadruplexes (G4s), the noncanonical nucleic acid secondary structure, form within guanine‐rich DNA or RNA sequences. G4s formation can affect chromatin architecture and gene regulation and has been associated with various cellular functions, including DNA replication, transcription, and genome maintenance. Visualizing and detecting G4s precisely in such processes is essential to increasing our...
The articles in a special collection of Biopolymers describe the ongoing evolution of peptide nucleic acid (PNA). It is a chimeric molecule consisting of both peptide and nucleic acid structural elements, first reported by Danish scientists more than 30 years ago. The uncharged and unnatural backbone of PNA sparked great interest in its use in biology. More recently, chemical modifications to the...
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